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Although available evidence suggests that srom may be a promising treatment option for oud, it is important to note that only four clinical trials have evaluated its efficacy in this context (mostly compared to methadone), with high heterogeneity across studies. To evaluate the efficacy of srom as an alternative maintenance pharmacotherapy for the treatment of opioid dependence. All studies published up to october 2010 and assessing srom for omt in adult.

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Srom starting doses should be based on the individuals opioid tolerance and risk of toxicity. No clear evidence for one approach over the other from the limited literature. An abrupt stop and start may result in higher rates of withdrawal while doses are being adjusted. Srom is proven to have advantages compared to methadone, such as less impact on qtc, less drug interactions, less symptoms of depression and anxiety, while having similar retention rates, nonopioid substance use, and adverse events.

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