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You have to actually step on the dice in the middle of the room. When entering a dice room, always let go of your movement keys immediately after entering it, so you can check what number it is before activating it. Dice room carried a weak run all the way to the end.
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So fellow redditors, what are your best dice room stories, good or bad? The screen will shake and the room's effect will resolve. If i'm checking dice rooms, i'm pretty much exclusively looking for a 5 room. 5 is always helpful unless you're trying to play fast (in which case you're probably not checking dice rooms), vs all the others being either highly situational or just straight up bad.
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5 is pretty good. Dice rooms are special rooms that can randomize many elements of the run. Dice rooms require two keys to be opened, unlike most other special rooms. For a dice room to spawn, two things must happen; First, the game must decide that a sacrifice room will spawn that floor.