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Crafting portable slot is a fixed recipe and requires 8 coins. Crafting an active item destroys your current one and spawns new pickups (which i think still depend on the room you're in, so do this in the secret room for bone hearts). Dice rooms are special rooms that can randomize many elements of the run.
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Dice rooms require two keys to be opened, unlike most other special rooms. For a dice room to spawn, two things must happen; First, the game must decide that a sacrifice room will spawn that floor. What does dice room 1 do in binding of isaac?
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Basically you have to use a new item called clear rune, which can only be found in secret rooms or as a prize from the crane game. This is the only item i know of that can break the game with no help from other items. All you need is a room full of pickups (see blank + dice shard for how to do that), and then a way to damage yourself. Dice rooms are special rooms that can randomize many elements of the run. Dice rooms require two keys to be opened, unlike most other special rooms.
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