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You have to actually step on the dice in the middle of the room. When entering a dice room, always let go of your movement keys immediately after entering it, so you can check what number it is before activating it. Especially on a good run you don't want to accidentally ruin it by stepping on a 6.
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Dice room 5 is the best thing since jpeg compression, it's a forget me now without losing your active. Just so much more loot, almost a guaranteed win. Hard mode dark room run i got a 5 room in depths 2 and i had a hermit card. This can be used to quickly gain progress tied to the number of mom's heart kills.
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Hearts, coins, keys, bombs, etc. ) in the room. Which type of dice room you like the most? The 5 because there's no downside to it. I think d6 is the best for those who dare to play bad runs without holding r key down. 4 and 5 are by far the best ones but i guess room 4 since that one is always nice.