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My first dice room was in the cathedral, had a one, and gave me lord of the flies. I was so confused, i thought it was like a ritual ground or something. My second dice room gave me a number one ludovico with a bunch of really weird effects that changed every room.
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Why the dice rooms are really good. So i was doing an azazel run for unlocks on hard, and i made it to the cathedral without any damage ups. This is where azazel's op brimstone really tapers off because he does so little damage to everything past the depths. They're a thing hidden behind two key doors.
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Most of them just reroll the items currently in the room, but one rerolls all of your current items and the other rerolls the floor you're on. Dice rooms randomize many aspects of the game, depending on the number printed on the very large red dice embedded in the floor. Stepping onto this die activates its effect. This can only be done once per room. I found a dice room that changed all my crappy items(really crappy) and got lord of the flies + orbital stationary tears of fear/charm that was also piercing and spectral and gigantic.
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